This bug (CTD during loading MSFS 2020) has been with us since January 30th, 2025. Since driver version 580.88, CTDs during MSFS 2020 loading with DX11 selected in the game settings occur even without the NVIDIA app installed, so the situation is now even worse than before.
If you want to have the latest NVIDIA drivers installed, MSFS 2020 must be set to DX12 instead of DX11 until NVIDIA, Asobo, Microsoft release a fix.
Please make sure to participate in the linked thread to confirm you’re also affected by this bug.
https://forums.flightsimulator.com/t/msfs-2020-ctd-during-loading-with-or-without-nvidia-app-installed-dx11/732584