For those suffering repeated and seemingly unfixable crash to desk top issues there is a forum community troubleshooting guide that is worth checking out. It is comprehensive and collected quite a bit of useful information since the launch of MSFS.
The thread is now closed (at the request of @EpicPrimus, the OP) , however there is still lots of useful information contained within the thread.
There is also this thread which is currently open and has lots of work arounds and suggestions: