Probably not 1 arduino mega, since you won’t have enough pins. 
But yeah, pretty much. (Maybe apart from the dimmable light)
You might be limited by the VARs used by FBW, but you would be with any software implementation.
Since the new update is supports also any game controller. So as long as your controller/buttonbox/throttle quadrant, etc is showing up as a game controller, Mobiflight can map it.
Disclaimer: this is all second-hand knowledge. I don’t own a home cockpit myself.