I know it’s causing issues -that’s actually why I reported it as a bug some time ago.
https://forums.flightsimulator.com/t/msfs-2020-ctd-during-loading-with-or-without-nvidia-app-installed-dx11/732584
The good news is they’ve already fixed it in the beta version. So pretty soon you should be able to run DX11 with the latest Nvidia drivers without getting CTDs while loading MSFS 2020.
If you have any questions regarding CTD during MSFS loading or NVIDIA drivers, feel free to ask in the thread linked below.
https://forums.flightsimulator.com/t/msfs-2020-ctd-during-loading-with-or-without-nvidia-app-installed-dx11/732584