Hi @lolilol1975,
Do these topics describe what is happing to you with the mouse?
Mouse stops interacting with virtual cockpit:
https://forums.flightsimulator.com/t/mouse-stops-interacting-with-the-virtual-cockpit/123524
Freelook with mouse:
https://forums.flightsimulator.com/t/freelook-with-mouse-seriously-broken-since-update/341382