X52 (not Pro) - I am desperate!

My old X52 works fine also. Have you tried uninstalling all the Logitech/Saitek software ? You’ll loose the advanced profile programmation, but the joystick is well recognized in Windows 10 without it, and I’m able to use all the buttons and axis.

Tricks and hacks for X52/X52 pro - Self-Service / Peripherals - Microsoft Flight Simulator Forums