I was getting random CTDs (0xc0000005, 0x00007, VCRUNTIME140.dll…) on almost every flight after the latest update, even after testing virtually all of the proposed solutions.
For what it’s worth, switching off traffic, ATC voices, text-to-speech AND killing SpeechRuntime in Task Manager when starting a flight (SpeechRuntime.exe restarts with each game start, new flight or VR/normal mode switch) AND not opening popup menus (VFR etc.) during flight appears to have solved it for me - or at least reduced CTDs…
I have disabled Cortana, voice recognition etc. in Windows.
Win 10 20H2
16 GB RAM
Ryzen 5 2600
RX 5700 XT
HP Reverb G1