I did a couple of lfights to LOWI, though I admit not with an airliner only the Longitude, the HondaJet and the Vision Jet, all of them a lot smaller.
Still I like the place, flying the Alps is one of my favorites in Europe. The biggest challenge would be really low visibility, since LOC is offset from the runway and is transmitting you to follow heading 254, while the runway is 257, all this since the runway is not in line to the valley:
But I guess these are the exact reasons why it’s so polular with the flight sim community